Applications of Nexisense Sanitary Pressure Transmitters in the Pharmaceutical Industry: Precise Monitoring to Safeguard Drug Quality

The pharmaceutical industry bears the critical responsibility of safeguarding human health, and every production step must be strictly controlled to eliminate potential risks. As a core device for process monitoring, pressure transmitters play a vital role in pharmaceutical manufacturing. Sanitary designs, in particular, effectively ensure cleanliness and data accuracy. Nexisense sanitary pressure transmitters serve the pharmaceutical sector with reliable performance, helping enterprises improve process stability. This article provides comprehensive guidance from basic principles to practical applications.

Definition and Function of Pressure Transmitters

A pressure transmitter is an instrument that converts pressure signals into standard electrical signals. In the pharmaceutical industry, it is mainly used to monitor real-time pressure changes in pipelines, vessels, or cleanrooms. It ensures that process parameters remain within specified ranges, preventing quality issues or safety hazards caused by overpressure or vacuum conditions.

Nexisense products emphasize sanitary compatibility and support seamless integration with control systems, providing reliable data support throughout the pharmaceutical production process.

Working Principle Analysis

Nexisense sanitary pressure transmitters use a flush diaphragm to directly sense pressure signals. The core sensing element is a silicon pressure chip. When medium pressure acts on the flush diaphragm, it causes deformation of the chip and generates a millivolt-level signal. This signal is amplified, linearized, and temperature-compensated by the built-in processing circuit, then converted into standard outputs such as 4-20mA current, 0-10V voltage, or digital signals.

This working principle ensures stable signal transmission over long distances, making it suitable for distributed monitoring in pharmaceutical workshops.

Internal Structure Analysis

The structural design focuses on hygiene and durability. The diaphragm adopts a 316L stainless steel flush diaphragm structure, directly exposed to the medium, with no dead zones and easy cleaning. The protective housing is corrosion-resistant, and the interfaces support quick clamp or flange connections, facilitating CIP/SIP cleaning in place.

The overall structure is compact, with an internal isolation diaphragm to prevent medium contamination of the sensing element. The protection rating reaches IP67 or higher.

Key Advantages

The flush diaphragm design eliminates scaling and clogging, removes hygienic dead zones, and complies with GMP requirements. The 316L material offers excellent corrosion resistance, vibration resistance, and impact resistance, making it suitable for high-temperature sterilization and chemical cleaning.

Multiple signal output options enable easy connection with PLC, DCS, or SCADA systems, supporting remote monitoring. High accuracy and fast response ensure reliable data in demanding pharmaceutical environments while reducing contamination risks.

Application Scenarios in the Pharmaceutical Industry

In fermentation tanks and reactors, pressure is monitored to prevent overpressure explosions or vacuum collapse. During purification and separation processes, transmitters are used for filter pressure control to prevent clogging and yield loss.

Cleanroom differential pressure monitoring maintains positive pressure to block external contaminants. In sterilizers and freeze dryers, vacuum levels are tracked in real time to ensure process consistency. In pipeline conveying systems, fluid pressure is monitored to optimize pumping efficiency.

In these scenarios, sanitary pressure transmitters help companies comply with FDA and EU GMP standards while enhancing product quality traceability.

Measurement Methods and Installation Standards

The measurement adopts a direct-contact method, with the flush diaphragm in close contact with the medium. Clamp connections are preferred for installation, ensuring quick, contamination-free assembly. Installation locations should be selected at points with stable pressure, avoiding vibration and dead zones.

Gauge pressure, absolute pressure, or differential pressure modes are supported. Output signals are connected to supervisory systems to enable automatic alarms and control.

Maintenance and Care Guidelines

Maintenance focuses on regular CIP cleaning of the diaphragm and inspection of seal integrity. Annual calibration is recommended to verify accuracy and record deviations. After exposure to corrosive media, prompt flushing is required.

Store the device in a dry, well-ventilated environment and avoid extreme temperatures. Proper maintenance extends service life and ensures long-term hygienic compliance.

Technical Specifications Overview

Typical Nexisense specifications include: diaphragm material 316L stainless steel; measuring range from -0.1MPa to 40MPa; accuracy from ±0.1% FS to ±0.5% FS. Outputs include 4-20mA, HART, or digital signals. Operating temperature ranges from -40°C to 125°C (up to 150°C during sterilization). Interfaces include 1.5-2 inch clamp connections, with protection rating IP67.

Compliance and Customization Options

The products comply with sanitary certifications such as 3A and EHEDG, and support customization based on tank size or signal requirements to better adapt to specific processes.

Frequently Asked Questions

Why are flush diaphragms suitable for pharmaceutical applications?
The dead-zone-free design makes them easy to clean and prevents contamination.

How is high-temperature sterilization handled?
The 316L material withstands 150°C steam, ensuring structural stability.

What should be done if the output signal is unstable?
Check grounding and cable shielding, and keep the device away from electromagnetic interference.

How is cleanroom differential pressure monitored?
Use low-range differential pressure models with high accuracy.

Is wireless transmission supported?
Some models integrate wireless functions and support IoT expansion.

Conclusion

Sanitary pressure transmitters are indispensable in the pharmaceutical industry, ensuring precise pressure control throughout the entire process from raw material handling to finished product packaging. With advanced flush diaphragm design and reliable performance, Nexisense provides efficient monitoring solutions. Through proper application and maintenance, pharmaceutical companies can significantly enhance production compliance and product quality. In an era of increasingly strict drug safety requirements, such equipment is not merely a tool, but a guardian of quality, supporting sustainable development and market competitiveness for pharmaceutical enterprises.